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Similarly, in studies of AC2, the Lgr5-binding octapeptide, Sh-Polypeptide 9, and AcSDKP, which promote the proliferation of various cell types, including DPCs, HFSCs, and matrix cells, do not demonstrate therapeutic effects in vivo [95,99,110,113]

In the National Health and Nutrition Examination Survey of U.S

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These findings suggest that kokumi substances are divided into at least two groups: one that exerts its effect via interactions with kokumi receptors, and another that directly binds with T1Rs and other G-protein-coupled receptors and exerts its effect by allosteric modulation of these receptors