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However, in case of the ASCT2, studies showed that cysteine is actually a competitive inhibitor and not a substrate for ASCT2 ( Figure 1 via Multidrug Resistance Protein 1 exporter (MRP1), is cleaved extracellularly by -Glutamyl transferase (GGT) forming -Glutamyl-X substrate and Cysteinyl-Glycine

The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA

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doi:10.1055/s-0036-1580693

In these cells, modulation of xCT is exploited to shape a tumor microenvironment conducive to increased aggressiveness

Use : Preferred for applications where saline is required and multi-dose access is needed