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Since cirrhosis and hepatocellular carcinoma (HCC) as major complications of CLD contribute to liver-related morbidity and mortality, effective management of patients with CLD is crucial to reduce the forthcoming disease burden and health expenditures [3]

However, GSH is found in intracellular organelles including endoplasmic reticulum (ER), nucleus, and mitochondria to control compartment-specific needs and functions (Mari et al., 2009, 2010)

Macfie, J

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Developing personalized interventions also requires a better understanding of how patients respond differently to treatments, all based on a precise understanding of disease mechanisms

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