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Dosing typically begins at a lower dose, suggested initiation of 4 units (0.04 mL) weekly for the first 4 weeks, then escalates according to a titration schedule: Weeks 1-4: Inject 4 units (0.04 mL) one time per week Weeks 5-8: Inject 8 units (0.08 mL) one time per week Weeks 9-12: Inject 18 units (0.18 mL) one time per week Weeks 13-16: Inject 30 units (0.3 mL) one time per week Week 16+: Inject 44 units (0.44 mL) one time per week Dosing may deviate from this pattern to accommodate patient-specific needs

Shi H, Bencze KZ, Stemmler TL, Philpott CC

References (Scientific Literature) PMCID: PMC2249747 (1) PMCID: PMC8078644 PMCID: PMC7462336 PMID: 23631796 PMID: 11056412 PMID: 10575337

10.1016/S0531-5565(02)00175-4

Many researchers have reported mechanisms of DZN toxicity in various cell types

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