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In contrast, pathways typically linked to cellular protection, including MYC targets V1, protein secretion, DNA repair, oxidative phosphorylation, the unfolded protein response, MTORC1 signaling, and adipogenesis, were markedly downregulated (Figure 4B and Supplemental Figure 6A)

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The authors describe cases where the only visible symptoms were persistent, non-itchy hyperpigmented patches or polymorphic skin lesions