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The role of mechanotransduction of the high venous pressure in the pathogenesis of varicose vein formation has not been adequately investigated despite a good progress in understanding the mechanomolecular mechanisms involved in transduction of high blood pressure in the arterial wall

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These biomarkers are also used to track the efficacy of antioxidant therapies, with decreasing levels of MDA and 4-HNE indicating effective intervention [35]

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