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Patients with diabetes, and patients with diabetes with CVD were recruited from diabetes and endocrine inpatient unit and the cardiology unit, respectively, while healthy controls and patients with obesity without diabetes were recruited voluntarily from the general population through local advertisements and word of mouth

In patients with T2DM and other metabolic abnormalities, elevated SELENOP levels exacerbate IR and reduce the efficiency of insulin transport into the CNS, thereby compounding metabolic dysfunction and possibly contributing to neurodegenerative processes [224]

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Collectively, the gut microbiota profile of the VPA-ASD groupmarked by an elevated Firmicutes/Bacteroidota ratio and an increase in pathobionts like Desulfovibrionalesaligns with established dysbiotic features of ASD

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