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Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer

Association between vitamin D3 levels and frailty in the elderly: A large sample cross-sectional study

Bioactive metabolites in botanical drugsflavonoids, alkaloids, saponins, and othersdemonstrate therapeutic potential across disease stages through multi-tiered mechanisms, ranging from direct antioxidant defense to systemic regulation of metabolic-inflammatory balance

All experiments were repeated 3 times, and data were analyzed using Students t test (2 tailed) or 2-way ANOVA with multiple-comparisons post hoc tests, as appropriate

In an ethanol-induced liver injury model, melatonin exerted NrF2-mediated anti-ferroptosis action through the modulation of BMAL1 [432]