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Cancer 12 (9), 14151422

This strategy is predicated on the recognition that transient, localized bursts of radicals, such as mitochondrial O 2 or NADPH oxidase-derived radicals, are not merely toxic byproducts but critical endogenous signaling molecules that drive beneficial adaptations, including enhanced mitochondrial biogenesis, improved glucose metabolism, and elevated cellular stress resistance through pathways like AMPK and NRF2 [87, 106, 154, 178, 229, 251]

This protects it from metabolism by your liver

Nat Rev Urol (2022) 19(10):58196

HIGHLY BIOAVAILABLE MELATONIN LIQUID - With conventional liquid or powder formulations, only a small percentage survives the gastrointestinal system, which is why you see such large quantities in other products

Deleu C, Cousrtaut M, Niogret M-F, Larher F