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Description
Aside from esophageal manifestations, GERD can cause extra-esophageal symptoms such as chronic cough, laryngitis, asthma, and dental erosion, thus indicating its systemic significance [8,9]

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Nat Med (2020) 26:163643
Shires TK, Brummel MC, Pulido JS, Stegink LD

Reductions in b* indicate an objective, measurable improvement in skin pigmentation uniformity

Those decisions are made based on labs and a clinical consultation, not a general protocol
