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Molecular pathophysiology and potential therapeutic strategies of ketamine-related cystitis

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This study was supported by an NIH grant HD43108 (to M.N.F.), a Grant-in-Aid for Scientific Research B-18390113 (to J.N.), B-16390478 (to D.A.), B-00265878 (to K.S.) and CER-24659726 (to K.S.) from the Japan Society for the Promotion of Science

Previous studies have demonstrated that Treg cell differentiation requires a two-step model wherein robust stimulation via the T-cell antigen receptor (TCR) induces CD25 expression in precursor cells, which is subsequently enhanced by IL-2 stimulation, ultimately leading to Foxp3 expression [155157]

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Artificial flavors, neon dyes, and overly sweet formulas that once felt normal now feel unnecessarily intense to a lot of families