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What is notable is the very frequent spatial correlation with these B cell collections of myelin injury in the subpial cortex as well as spinal cord white matter, raising the possibility that these cells release a myelinotoxic substance (Magliozzi et al., 2007

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This selectivity profile is what distinguishes FOXO4-DRI from broader cytotoxic agents and makes it the primary peptide tool for selective senescent cell elimination in the cellular senescence research field