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So far, fourteen natural alkaloids have been reported to possess inhibitory potentials towards IKK ( Figure 13-15 ), including berberine ( 43 ), vinpocetine ( 44 ), cryptopleurin ( 45 ), matrine ( 46 ), tetrandrine ( 47 ), piperlongumine ( 48 ), daphnipaxianine A ( 49 ), pipernigamides E-G ( 50-52 ), tulipiferamide A ( 53 ), herbimycin A ( 54 ), himalesine ( 55 ), and ellipticine ( 56 ) [115, 161-169]

Li W, Feng G, Gauthier JM, Lokshina I, Higashikubo R, Evans S, et al

Mitochondria-targeted antioxidants as a therapeutic strategy for chronic obstructive pulmonary disease

doi: 10.1016/j.numecd.2014.01.002 2 AmarJ.BurcelinR.RuidavetsJ

Real-time PCR was performed with SYBR Green Master Mix (Roche, Basel, Switzerland) on a QuantStudio 5 system (Applied Biosystems, Waltham, MA, USA), using the following cycling conditions: 95 C for 10 min, followed by 40 cycles of 95 C for 15 s and 60 C for 1 min