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The combination of strong GLP-1 appetite suppression with meaningful GIP-mediated metabolic improvement creates a synergistic effect that exceeds what either receptor could produce alone, a principle similar to why peptide stacking sometimes outperforms individual compounds

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Our data further indicate that the TGF/Smad pathway is important in the pathogenesis of IDD and the natural healing process following PELD

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To maintain the cyclic structure of the LyP-1 peptide as well as the CendR motif, DOTA was conjugated with the -NH 2 of the cysteine at the N-terminus of LyP-1 either directly or via the 6-aminocaproic acid (ACP) spacer (Fig