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Description
The condition results from overactive sympathetic stimulation of eccrine sweat glands , independent of thermoregulatory need
More specifically, the conditions of high cytosolic Ca 2+ leading to mitochondrial Ca 2+ overload, combined with unregulated ROS production, trigger the opening of the MPTP, a nonselective inner membrane channel
[DOI] [PubMed] [Google Scholar] 297.Rajasekaran NS
As a result, inhibitors designed for IRAK4 might inadvertently act on IRAK1 as well
ErmundASchtteAJohanssonMEVGustafssonJKHanssonGC
Ranson H, Hemingway J
