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In the case of skin necrosis, two types are distinguished: dry gangrene, which is not caused by bacteria, and wet gangrene, which develops due to bacterial proliferation near the wound

In this essay, we review the recent progress in the understanding of the mechanism underlying cuproptosis, revisit the roles of p53 in metabolic regulation and iron-sulfur cluster and glutathione biosynthesis, and propose several potential mechanisms for wild-type and mutant p53-mediated cuproptosis regulation.