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FGF21 Agonists Hepatic lipid homeostasis is tightly controlled through the influences of insulin, free fatty acids, sterol regulated element-binding protein (SREBP), and nuclear receptors and associated regulatory molecules such as the liver X receptors (LXRs) and peroxisome proliferator-activated receptor (PPAR), respectively

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Concurrently, systemic inflammation surged, with serum IL-1, IL-6, and TNF- levels significantly exceeding the control groups (Fig
