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Presently, isatuximab is approved for the treatment of RRMM in combined therapy with pomalidomide and dexamethasone [79] and, in patients who have undergone two prior therapies, in combination with carfilzomib and dexamethasone [80]

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The rash (Figure 1) begins as maculopapular lesions in a unilateral, dermatomal distribution that rarely crosses the midline

Haematological malignancies: Myeloproliferative disorders (polycythaemia vera, chronic myeloid leukaemia) and some lymphomas increase B12-binding proteins, particularly haptocorrin, raising measured serum levels