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Accurate assessment of the scope of this phenomenon remains challenging due to its predominantly clandestine nature, frequent polypharmacy, and the widespread availability of unregulated substances of uncertain composition and purity

coli K-12 strain was selected as a Gram-negative control due to its well-characterized lipopolysaccharide (LPS)-induced inflammatory properties and regulatory role in EMs pathogenesis [27, 44]

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established the ability of the gut microbiota to conjugate BAs with different molecules like amino acids, producing phenylalanocholic acid, tyrosochilic acid, and lithocholic acid, which are found in humans and enriched in patients with inflammatory bowel disease or cystic fibrosis (94)

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Ghorbel Koubaa F, et al