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Nitro fatty acids Nitro-fatty acids (NO 2 -FAs) are endogenous signalling mediators with strong anti-fibrotic and anti-inflammatory activities [286], able to promote NRF2 activation through the interaction and reversible post-translational modification of C273 and C288 present in the stress sensing domain (IVR) of KEAP1 [287]
Recent studies have revealed that neuronal metabolic reprogramming, characterized by PDK4-mediated inhibition of pyruvate dehydrogenase and altered expression of PKM2/PKM1 isoforms, contributes to early-stage Alzheimers and Parkinsons diseases
Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M
Redox signaling, in which the ROS H 2 O 2 acts as the signaling molecule, is a well-established concept (see [336, 337] for in-depth reviews)
10.3389/fneur.2022.829926 13 DongZ.WanD.LiG.ZhangY.YangH.WuX.et al (2020)
