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3.5 Methylation changes are associated with peripheral blood cell subpopulations and signaling pathways linked to immune response Given that our DNA methylation analysis was performed using whole peripheral blood samples, we applied an in silico immune cell deconvolution approach to estimate the immune cell composition associated with the DMRs identified in this study

Only 21% of the individuals in this sample exhibited mtDNA or nDNA mutations or chromosomal abnormalities, according to the researchers

10.1046/j.1365-313X.2003.01943.x 47 KouaD.CeruttiL.FalquetL.SigristC

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However, for safety reasons, it is necessary to adjust drugs' concentrations to understand their applicability in clinical trials