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Knockdown of AdipoR1 decreased the protective effects of schisandrin A in a DN mouse model, while the AdipoR1 agonist gramine exerts the opposite effect, indicating that AdipoR1 may be a potential target of SA in a DN model [246]

The experimental autoimmune encephalomyelitis (EAE) animal model of MS has proven the pathogenic function of myelin-reactive T cells in MS pathogenesis (Laaker et al., 2021)

Karimi M, Eslami M, Sahandi-Zangabad P, Mirab F, Farajisafiloo N, Shafaei Z, et al

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(72) reported in a randomized controlled trial that the Yiqi Yangyin Huoxue formula combined with acupuncture lowered IL-1, IL-17, and serum amyloid A (SAA) levels, and improved blood glucose and renal function, indicating a synergistic effect with core acupoints such as ST36, SP6, and BL23
