nature bound glutathione review Glutathione-Related Enzymes and Proteins: A Best Glutathione Supplement | 4

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Fibroblast activity and collagen synthesis

E.Gonzalez-BaronS.CastillaC

doi: 10.1016/B978-0-12-823355-9.00017-1 200 RanaS.MardarveranP.GuptaR.SinghL.WahidZ

A lack of AhR agonists may lead to a reduction in glucagon-like peptide-1 (GLP-1) and IL-22 secretion, thereby increasing intestinal permeability and exacerbating inflammation, which further worsens IBS symptoms (76)

This second process means that the GSH:GSSG ratio measured in tissue or whole cell extracts does not report on the actual glutathione status in specific compartments but is rather a composite value of GSH:GSSG ratios, which may differ widely between different subcellular locations (Noctor et al., 2013)