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Mit zunehmendem Alter, bei oxidativem Stress, Belastungen mit Fremdsubstanzen wie Schadstoffen und Medikamenten und anderen schdigenden Einflssen knnen keine ausreichenden Mengen an Glutathion (mehr) gebildet werden

Li BL, Teng JK, Chen S, Yang JM, Liu XQ, Zhang J, et al

Substitution of PtGSTU19 Tyr 160 by an alanine, cysteine, or phenylalanine residue (PtGSTU19Y160A, PtGSTU19Y160C, and PtGSTU19Y160F variants, respectively) and PtGSTU20 Cys 160 by a tyrosine residue (PtGSTU20C160Y) did not affect (or slightly affected) the affinity for the electrophilic substrate and the turnover number of both enzymes (Supplementary Table S4)

[DOI] [PubMed] [Google Scholar] 408.Chen Y, He W, Wei H, Chang C, Yang L, Meng J, et al

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