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Pathophysiology of multiple sclerosis and the place of teriflunomide

The researchers observed an increase in the 5 hmC/5 mC ratio compared to placebo-treated patients, which may enhance the biological effects of DNMTis

The AMP genes -defensin 2/defensin-4 (HBD2/DEFB4) and cathelicidin antimicrobial peptide (CAMP) are encoded by 1,25(OH) 2 D/VDR signalling in the immune cells, thus contributing to the innate immune defence (172, 173)

[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Prather AA, Leung CW
In particular, GRP significantly altered the community structure of the gut microbiota, increasing the abundance of Bacteroidetes and decreasing Firmicutes in comparison with the HFD group who did not consume GRP (Xu et al., 2020)
