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In line with this, another study reported that tubular epithelial cells treated with the CPT1 inhibitor etomoxir showed an increase of gene expression typical of fibrosis, such as -SMA and Vimentin (Figure 1)

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According to EFSAs Panel on Dietetic Products, Nutrition and Allergies, a single caffeine intake of up to 200 mg (about 3 mg/kg for a 70 kg adult) for a total daily intake of 400 mg of caffeine is safe