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Oral supplementation is usually sufficient for individuals with mild to moderate deficiency due to dietary insufficiency or malabsorption disorders

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However, some people, especially those with specific genetic mutations, might not absorb it as efficiently

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There is also a small risk of rupture / perforation of the rectum or bowel at the time of endoscopy (roughly 1 in 1000 cases), that may necessitate surgery

Hofman MS, 2021, 'UpFrontPSMA: A randomized phase II study of sequential 177Lu-PSMA617 and docetaxel versus docetaxel in metastatic hormone-naive prostate cancer (mHNPC).', in JOURNAL OF CLINICAL ONCOLOGY , LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol