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However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
2007;178(4 Pt 1):1398-1403
Interfering with their direct interaction with the immune cells through ligand-receptor bridges or indirect interaction through cytokines could potentially provide new treatment strategies for TED
doi: 10.1089/ham.2019.0143
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