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The mitochondrial pathway relies on the dynamic balance between pro-apoptotic proteins (e.g., BAX, BAK) and anti-apoptotic proteins (e.g., B-cell lymphoma-2 (Bcl-2)), reflecting regulatory imbalances in the Bcl-2 protein family [8]

ARTN 656 10.3390/nano10040656 [DOI] [PMC free article] [PubMed] [Google Scholar] 144.Newman JC and Verdin E (2014) Ketone bodies as signaling metabolites

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One challenge in curcumin-based therapies is its limited bioavailability, which can be addressed using nanoparticle-based delivery systems [48]

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