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10.1038/tp.2013.91 [DOI] [PMC free article] [PubMed] [Google Scholar] Ponzetto C., Bardelli A., Zhen Z., Maina F., dalla Zonca P., Giordano S., et al

2.8 Altered iron metabolism Iron accumulation is reportedly a mechanism that can lead to cellular damage in both neurodegeneration and metabolic dysfunction models, and iron-dependent programmed cell death (ferroptosis) is observed in both conditions (Du et al., 2024)

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When released to the circulation, the bone-derived FGF23 binds to its receptor in epithelial cells of the proximal tubules of the kidney leading to decreased expression the type II sodium-phosphate co-transporters, NPT2a (encoded by the SLC34A1 gene) and NPT2c (encoded by the SLC34A3 gene)