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10.1111/j.1438-8677.2010.00398.x 71 Hawrylak-NowakB.DreslerS.WjcikM

Enhancing SERCA activity may provide a potential strategy for improving sarcopenia associated with asthma (78)

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In addition transcriptome analysis showed increased expression of NADPH oxidase genes Cybb (Nox2) and Nox4 (Supporting information, Data S1), which are an additional source of ROS [83]

doi:10.1208/s12249-022-02209-9 127

Although the mouse results suggest that humans treated with ibuprofen may also show significant differences in CYPs and oxylipins, it is also likely that there are differences in how CYPs and oxylipins are altered in response to ibuprofen treatment in mice and humans