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Mice bearing IMR5 xenografts with a mean diameter of 5 mm were treated with 3 mg/kg DPI (P.O., 5 days/week), 30 mg/kg MitoQ (P.O., 3 days/week), or their combination (1.5 mg/kg DPI (P.O., 5 days/week) and 20 mg/kg MitoQ (P.O., 3 days/week))

Additional dose groups (including higher single-dose ranges) have been discussed in regulatory/nomination documents

Allergic reactions are rare but possible

NAD+ Dynamics

This enzyme is overactive in individuals with excess abdominal fat and metabolic dysfunction

The Solution: Follow structured cycling (8-12 weeks on, 4-6 weeks off) to maintain sensitivity and effectiveness across multiple cycles