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We detail the subsequent immune cascade that leads to loss of tolerance and targeted beta cell death

Pain Ther 4(2):169178

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Control Release 209 , 327336 (2015)

Metabolic reprogramming of DKD Kelli et al

For example, copper acts as a key cofactor for mitochondrial cytochrome c oxidase and is essential for meeting the energy demands of rapidly proliferating cells ( 2+ is extremely low under normal conditions, with an estimated upper limit of only 10 18 M ( Notably, dysregulation of copper metabolism can significantly impact physiological functions
