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Targeting Strategies for Early and Late Alzheimers Disease Drug development for AD has been hindered by numerous obstacles, including the selection of appropriate drug targets, the limitations of current biomarkers and animal models, and other factors such as delayed treatment initiation, dose-related side effects, and the challenge of overcoming the BBB

Reference: Kaiqiang Sun, Jiuyi Sun, Chen Yan, et

in 2005, stating that it was only performed with the aim of helping to evaluate genome-wide methylation [27]

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