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Mechanisms in endocrinology: clinical and pharmacogenetic aspects of the growth hormone receptor polymorphism

doi: 10.1016/j.colsurfb.2021.111681

In patients with breast cancer who are not responsive to anti-PD-1 therapy, combined therapy involving both V-9302 and anti-PD-1 may have a synergistic impact [115]

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Even minimal off-target interactions can lead to unintended modulation of neurotransmitter systems, potentially confounding therapeutic outcomes or exacerbating side effects