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The presence of CD38 ecto-nicotinamide nucleotidase in activated immune cells may reduce the availability of NAD + to bacteria and other pathogens and could limit the development or progression of infections

Experimental systems have been used to evaluate how AOD 9604 influences energy balance under controlled dietary and metabolic conditions [1]

Bacteriostatic water used for reconstitution should be discarded after 28 days to prevent pH shifts from bacterial growth

Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)