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They are typically used in cases with significant cartilage loss where autologous options (from the patients own tissue) may not be suitable

Arch Biochem Biophys 663:249258 Sorar G, Vergani L, Fedrizzi L et al (2007) Activities of mitochondrial complexes correlate with nNOS amount in muscle from ALS patients

The practical consequence is that most adults in their 40s and beyond are running on lower glutathione reserves than they had in their 20s, and the modern environment continuously demands more of it

Application tips: Vary the site of application

However, it has intolerable side-effects that limit its use, motivating the discovery of alternative therapeutics

Han Y, Gao C, Wang H, Sun J, Liang M, Feng Y, et al