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Therefore, intranasal administration of chitosan-modified nanoemulsions resulted in a higher drug concentration in the brain than administration of the free drug solution and positively affected in-vivo neurobehaviors

Methods are described in detail in the methods section and in the Supporting Information

Oxidative stress damage may also play a pivotal role in other inborn metabolic disorders, such as mitochondrial encephalopathies

Pregnancy All agents are considered safe in pregnancy including during conception and are continued right through pregnancy with exception of JAK inhibitors and ozanimod which at present are considered contraindicated in pregnancy

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H + is here a simplified notation of the actual chemical structure of the aqueous proton (whether H 13 O 6 + , H 5 O 2 + , or H 9 O 4 + , this is a debate beyond the topic of this article and covered by others [78, 103])