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Apoptosis is closely related to important cytokines, including apoptotic protease activator 1, Bcl-2 family, caspase family proteins, NLRP3 inflammasome, p62, tumor suppressor genes, and Fas signal transduction [78]

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IGF-1 possesses both, GH-like actions and insulin-like actions, whose effects in vivo depend on the dosage, length of treatment, and even route of administration [134, 135]