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Both Nrf1 and Nrf2 knockout mice have lower GCLC expression [114,115] and overexpression of Nrf1 and Nrf2 can induce the human GCLC promoter activity [104,116]

As the results are still scarce and inconsistent, more studies need to be done
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References Siderowf, A

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NaBPC157 The effects of NaBPC157 on chronic alcohol intoxication were examined