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stems revealed to exert significant amelioration in APAP-induced apoptosis, inflammation, and oxidative stress through regulation of mitogen-activated protein kinase and caspase-3 signaling pathway (Li et al., 2018)

Hypoxia increases HIF-1-mediated iron uptake through upregulation of TFRC and DMT1 expression, promotes the accumulation of ROS and affects cell susceptibility to ferroptosis (61,82)

A 123, 17301739

Nrf1 and Nrf2 may induce GCLC promoter directly and indirectly

Additionally, vitamin B12 is involved in the metabolism of homocysteine, an amino acid that, when elevated, can increase the risk of cardiovascular diseases

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