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4 Discussion The enteric nervous system (ENS), often referred to as the second brain, not only autonomously regulates local intestinal physiological functions but also engages in bidirectional communication with the central nervous system (CNS) via the gutbrain axis

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10.1126/science.aas9090 [DOI] [PMC free article] [PubMed] [Google Scholar] Martins R., Lithgow Gordon J., Wolfgang L

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These early effects reflect the melatonin and circadian regulation mechanism