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In hepatocytes, Hcy can be remethylated to generate methionine by methionine synthase (MS), which requires normal levels of folate and vitamin B 12 , and betaine homocysteine methyltransferase (BHMT), which requires betaine

assessed antioxidant capacity through the Folin-Ciocalteau and Trolox equivalent antioxidant capacity assays, noting that pH had a more significant impact on antioxidant capacity than the addition of cysteine

This is yet another reason why maintaining adequate body stores of reduced glutathione is very important to overall health

However, whether such crosstalk occurs during liver or kidney I/R remains to be investigated

It has been reported that biotic and abiotic stress often induces the overproduction of reactive oxygen species (ROS) such as the superoxide radical (O 2 ) and hydrogen peroxide (H 2 O 2 ) 14

Rate is usually judged on the basis of equivalent Cmax and Tmax while extent is judged on equivalent area under the concentration time curve (AUC)