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Nature 586:509515 Nair J, Nair A, Veerappan S, Sen D (2020) Translatable gene therapy for lung cancer using Crispr CAS9an exploratory review

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancer

(PubMed) Hatfield DL, Tsuji PA, Carlson BA, Gladyshev VN

Biomaterials 135 , 4252 (2017)

However, during aging, the homeostasis imbalance arises and progresses, leading to increased cytokine response (2- to 4-fold increase) mediated by the chronic activated innate immune system

These include nausea, diarrhea, and vomiting