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In another aspect, there is provided a method of generating monocytes and/or macrophages having a reduced inflammatory phenotype after contact with at least one agent, the method comprising contacting the monocytes and/or macrophages with an effective amount of at least one agent, wherein the agent is a) an agent that upregulates the copy number, amount, and/or activity of at least one target listed in table 1 and/or b) an agent that downregulates the copy number, amount, and/or activity of at least one target listed in table 2

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And mice were evaluated every 3 days for paw swelling scores and clinical scores, and the hind paw diameters were measured by a digital caliper

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