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However, in individuals with preexisting neoplastic conditions, excessive intake, particularly of synthetic folic acid, may increase cancer risk, although this relationship remains to be fully elucidated (61)

Hesperidin can modulate MAPK signaling by inhibiting the phosphorylation of MAPK kinases, such as p38, ERK and JNK

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In a recent smaller phase 1b study the non-steroidal, fexeramine-derived FXR agonist MET409 improved fat content (MRI-proton density fat fraction (PDFF)) over 12 weeks113 and is further evaluated alone or in combination with empagliflozin (SGLT2 inhibitor) in patients with both NASH and type 2 diabetes (NCT04702490)

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Radiat Res (1998) 149(3):25662
