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3g), but the H 2 O 2 -inhibition efficiency of ZMTP is much lower than that of natural catalase, as in catalase the oxoferryl porphyrin cation radical (P + -Fe IV = O) (rather than Fe V ) can form under the assistance of Tyr 354 residue, which favors the valence transition of Fe center during H 2 O 2 decomposition

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et al., 2020), Astragaloside IV (Jiang et al., 2017), Saikosaponin D (Wang J

Astragaloside IV inhibits doxorubicin-induced cardiomyocyte apoptosis mediated by mitochondrial apoptotic pathway via activating the PI3K/Akt pathway
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