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Persister cell derivation and treatments Persister cells were derived from treatment of HER2 amplified breast cancer BT474, EGFR mutant non-small cell lung cancer PC9 or Kuramochi ovarian cancer cells with 2 M lapatinib, 2 M erlotinib, or co-treatment with 10 M carboplatin and 100 nM paclitaxel, respectively, for at least nine days with fresh drug added every three days

Following the identification of candidate proteins through PLS-DA, linear mixed-effects models were used to evaluate the association of each protein individually with ARS

Gene expression is presented as TPM (Transcripts Per Kilobase Million mapped reads), whereby only reads that mapped uniquely in the genome were included in the calculation of TPM values

Unlike commercially available drugs that come in fixed dosages and formulations, compounded medications allow for greater flexibilitysuch as adjusting the dose, changing the delivery form, or removing inactive ingredients

To alter physiological H 2 S levels, we exposed heart tissue to ischaemia, which is predicted to increase the levels of H 2 S due to inhibition of its degradation by SQOR through the reduced CoQ pool 12,13

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