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Prevalent winds generate horizontal and sometimes vertical ocean currents: The winds blowing from the land towards the oceans (off-shore winds-moving away from the shore) drive warm surface water away from the coast resulting in the upwelling of cold water from below (This happens near Peruvian Coast in normal years

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Overcoming the peptide stability issues against proteolysis, which result in a short duration of activity and low bioavailability, is also crucial

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