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NNMT inhibitors reduced intracellular 1-MNA, increased intracellular NAD + and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis in adipocytes
In a 2021 study in obese mice, 5-amino-1MQ administration caused significant body mass reductions in the rodents, who achieved body composition and liver adiposity parameters that were comparable to the lean mice in the control group
However, strongest does not always mean best for every patient
